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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name MMP-9 siRNA
ncRNA Category siRNA
Disease name diabetic retinopathy (DR)
Species Bos taurus
Tissues/Cell_line bovine retinal endothelial cells
Methods siRNA transfection, zymography, qPCR, Western blot, ELISA
Expression pattern associated
Functional description In retinal endothelial cells, high glucose activated MMP-9, and inhibition of its activation (by pharmacologic inhibitor or siRNA) ameliorated accelerated apoptosis.
PubMed ID 20220057
Year 2010
Title Role of matrix metalloproteinase-9 in the development of diabetic retinopathy and its regulation by H-Ras.
Drug-related ncRNA NO

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